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Constantinople was a thriving city in the 1200s mainly because of its location on a major trade route between:

  1. China and southern Africa

  2. the Atlantic Ocean and the Baltic Sea

  3. the Inca Empire and the Aztec Empire

  4. Asia and eastern Europe

The correct answer is: Asia and eastern Europe

Constantinople's significance in the 1200s can largely be attributed to its strategic position as a crossroads between Asia and eastern Europe. The city was located on the Bosporus Strait, which connects the Black Sea to the Mediterranean Sea. This location enabled it to control and facilitate trade routes that linked the rich markets of Asia, including the Silk Road, with the emerging economies of eastern Europe. Trade was vital for the city's economy, enabling the exchange of goods such as spices, silks, and precious metals. Additionally, Constantinople served as a cultural melting pot, which was a consequence of its vital trade connections that brought together diverse peoples and cultures in commerce and interaction. The other options do not accurately represent the historical trade dynamics relevant to Constantinople during this period. For instance, trade routes connecting China and southern Africa or the Atlantic and Baltic regions did not pass through or significantly influence Constantinople. The Inca and Aztec empires were located in the Americas, far removed from the European trade networks of the time, and thus did not relate to the city's prosperity in the 1200s.